[Central interleukin-1beta involved in modulation of motor behavior in novelty stress rats].

ABSTRACT

OBJECTIVE: To investigate the effect of central interleukin-1beta (IL-1beta) on motor behavioral responses in novelty stress rats. METHODS: The novelty stress was elicited by novel environmental stimuli with novelty stress box. The intracerebrolventricular (ICV) cannula and microinjection were performed with rat brain stereotaxic system. Movement behaviors of rats were monitored by behavioral radio-telemetry system. As behavior index, mean percent immobility (MPI) was used to assess immobility of rats. RESULTS: The decrease of MPI was remarkably elicited by novel environmental stimuli. In non-stressful condition, ICV anti-IL-1beta antibody did not influence the MPI. The decrease of MPI induced by novel environmental stimuli was significantly blocked by ICV pretreatment with anti-IL-1beta antibody. In novel stress, MPI of rats was not affected by ICV injection of non specific IgG. CONCLUSION: Central interleukin-1beta plays an important role in modulation of motor behavioral response to novelty stress.