A novel one-pot four-component access to tetrahydro-beta-carbolines by a coupling-amination-aza-annulation-Pictet-Spengler sequence (CAAPS).

Karpov, Alexei S; Oeser, Thomas; Müller, Thomas J J

Karpov, Alexei S; Oeser, Thomas; Müller, Thomas J J.

Afiliação

Karpov AS; Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.

Chem Commun (Camb) ; (13): 1502-3, 2004 Jul 07.

Article em En | MEDLINE | ID: mdl-15216351

ABSTRACT

ABSTRACT

The four-component coupling-amination-aza-annulation-Pictet-Spengler (CAAPS) sequence of acid chlorides 1, terminal alkynes 2, tryptamine derivatives 6, and acryloyl chloride derivatives 4 represents a facile and rapid one-pot access to tetrahydro-beta-carbolines 7 in moderate to good yields.

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Base de dados: MEDLINE Idioma: En Ano de publicação: 2004 Tipo de documento: Article

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Base de dados: MEDLINE Idioma: En Ano de publicação: 2004 Tipo de documento: Article