Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder.
Arch Gen Psychiatry
; 61(7): 738-44, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15237086
ABSTRACT
BACKGROUND:
Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder.OBJECTIVE:
To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys.DESIGN:
Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline.SETTING:
A community-based sample of twin boys.PARTICIPANTS:
Five hundred fourteen male twins aged 8 to 17 years. MAIN OUTCOMEMEASURE:
Conduct disorder.RESULTS:
There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction.CONCLUSION:
This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.
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Base de dados:
MEDLINE
Assunto principal:
Violência Doméstica
/
Transtorno da Conduta
/
Doenças em Gêmeos
/
Monoaminoxidase
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article