Association between lenticulostriate vasculopathy (LSV) and neonatal intraventricular hemorrhage (IVH).
J Perinatol
; 24(11): 700-5, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15254561
ABSTRACT
OBJECTIVES:
To determine whether there is an unconfounded association between neonatal intraventricular hemorrhage (IVH) and lenticulostriate vasculopathy (LSV (also known as thalamostriate or mineralizing vasculopathy)). STUDYDESIGN:
During the conduct of the Magnesium and Neurologic Endpoints Trial (MagNET), a randomized controlled trial involving maternal, hence fetal, exposure to antenatal magnesium sulfate in the context of preterm labor, head ultrasounds were obtained for each of the surviving neonates. Because of our previous experience in the diagnosis of LSV, when ascertaining the presence of IVH, as called for by the research protocol of our study, the presence or absence of LSV was also determined.RESULTS:
We found LSV to be relatively prevalent (10% (14 of 140) among surviving babies). More importantly, it was significantly associated with the occurrence of neonatal IVH, even when controlled for possible confounding (adjusted OR 9.8, 95% confidence interval 1.3 to 73.1; p=0.03).CONCLUSION:
Given the known relationships between IVH and neonatal morbidity and mortality, the finding of a statistically significant association between neonatal IVH and LSV may suggest more substantial implications for the latter than previously believed.
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Base de dados:
MEDLINE
Assunto principal:
Hemorragia Cerebral
/
Doença Cerebrovascular dos Gânglios da Base
Tipo de estudo:
Clinical_trials
/
Guideline
/
Risk_factors_studies
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article