Direct synthesis of 4-arylpiperidines via palladium/copper(I)-cocatalyzed Negishi coupling of a 4-piperidylzinc iodide with aromatic halides and triflates.
J Org Chem
; 69(15): 5120-3, 2004 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-15255748
ABSTRACT
A general procedure for the synthesis of 4-arylpiperidines via the coupling of 4-(N-BOC-piperidyl)zinc iodide with aryl halides and triflates is presented. The reaction requires cocatalysis with both Cl(2)Pd(dppf) and a copper(I) species. An improved, safer procedure for the activation of zinc dust is also presented.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article