Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability.
Bioorg Med Chem Lett
; 14(16): 4161-4, 2004 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-15261262
ABSTRACT
Modification of lead compound 1 by reducing lipophilicity in the P3 group produced a series of low molecular weight thrombin inhibitors with excellent potency in functional assays, metabolic stability, and oral bioavailability. These modifications led to the identification of two optimized compounds, 14 and 16.
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Base de dados:
MEDLINE
Assunto principal:
Antitrombinas
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article