15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression.
J Neuroimmunol
; 153(1-2): 132-42, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15265671
ABSTRACT
We studied the role of 15-deoxy-delta (12,14)-PGJ2 (15d-PGJ2), a macrophage inhibitor with reported therapeutic effects on experimental allergic encephalomyelitis, in human astrocyte activation in vitro. 15d-PGJ2 inhibited a broad range of astrocyte inflammatory gene expression induced by IL-1, including cytokines (TNFalpha and IL-6), chemokines (RANTES/CCL5 and IP-10/CXCL10) and inducible nitric oxide synthase. 15d-PGJ2 inhibited transactivation of NF-kappaB-dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN-induced Stat signaling pathways. Our results demonstrating 15d-PGJ2-mediated astrocyte deactivation through inhibition of NF-kappaB are similar to those described for macrophages, and add astrocytes as additional targets for this prostaglandin (PG).
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Base de dados:
MEDLINE
Assunto principal:
Prostaglandina D2
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Astrócitos
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Citocinas
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NF-kappa B
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Interleucina-1
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Quimiocinas
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Sistema de Sinalização das MAP Quinases
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article