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Isoflavones in breast cancer chemoprevention: where do we go from here?
Kumar, Nagi; Allen, Kathryn; Riccardi, Diane; Kazi, Aslamuzzaman; Heine, John.
Afiliação
  • Kumar N; Department of Nutrition, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, University of South Florida College of Medicine, Tampa, Florida, USA. kumar@moffitt.usf.edu
Front Biosci ; 9: 2927-34, 2004 Sep 01.
Article em En | MEDLINE | ID: mdl-15353326
Based on the evidence from epidemiological, animal, in vitro data and human clinical trials, it is evident that isoflavones are promising agents for breast cancer chemoprevention. It is also evident that the form of isoflavone used (purified vs soy products), dose of isoflavone used (low vs high), timing and duration of exposure of isoflavones appears to play a major role in determining agonistic or antagonistic effects. Collectively, these isoflavones have enough evidence to warrant use in a number of clinical trials to examine its efficacy as a potential chemopreventive agent for breast cancer. In this comprehensive review, we attempt to summarize the evidence demonstrating the potential use of isoflavones in breast cancer chemoprevention and the rationale to examine a combination of biochemical, morphological and molecular intermediate endpoint biomarkers of breast cancer risk to examine the efficacy of this promising agent.
Assuntos
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Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais / Anticarcinógenos / Isoflavonas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais / Anticarcinógenos / Isoflavonas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article