Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice.
Brain Res
; 1023(1): 157-62, 2004 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-15364032
ABSTRACT
We measured preprocortistatin mRNA expression in young and aged transgenic (Tg) mice overexpressing the human beta-amyloid precursor protein (hbetaAPP) under the platelet-derived growth factor-beta promoter. Our findings suggest that the significant increase in hippocampal cortistatin mRNA expression during normal aging is significantly attenuated in Tg mice at an age known to exhibit beta-amyloid protein (Abeta) deposition. These deficits in cortistatin expression may play a role in the deficits in hippocampal-dependent spatial learning and sleep/wake states previously demonstrated in aged Tg mice.
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Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
RNA Mensageiro
/
Regulação para Baixo
/
Precursor de Proteína beta-Amiloide
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article