Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells.
Circulation
; 110(13): 1847-54, 2004 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-15381647
ABSTRACT
BACKGROUND:
Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. METHODS ANDRESULTS:
Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.CONCLUSIONS:
G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Fator Estimulador de Colônias de Granulócitos
/
Mobilização de Células-Tronco Hematopoéticas
/
Infarto da Artéria Cerebral Média
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article