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A new role for chondrocytes as non-professional phagocytes. An in vitro study.
Castillo, Elena Cristina González; Kourí, Juan B.
Afiliação
  • Castillo EC; Experimental Pathology Department, Center of Research and of Advanced Studies from IPN (CINVESTAV-IPN), Mexico, D. F., 14-740, Mexico.
Microsc Res Tech ; 64(3): 269-8, 2004 Jun 15.
Article em En | MEDLINE | ID: mdl-15452894
Chondrocytes are capable of engulfing latex particles, cell detritus, and necrotic and apoptotic remains in vitro. It is conceivable that chondrocytes might be involved in the clearance by phagocytosis of different materials within the cartilage. In fact, so far there is no evidence for the presence of "professional phagocytes" (macrophages and neutrophils) in this tissue. Chondrocyte suspensions obtained from rat knees and hips were cultured to assess phagocytosis of latex particles (1 microm), articular cartilage detritus, and necrotic and apoptotic chondrocyte remains (induced by VP-16 1 mM). We observed that chondrocytes phagocytosed latex particles as evaluated by confocal microscopy and flow cytometry. In addition, we observed that chondrocytes phagocytosed articular cartilage detritus and necrotic and apoptotic VP-16 induced-chondrocytes, as observed by bright field microscopy and transmission electron microscopy.
Assuntos
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Base de dados: MEDLINE Assunto principal: Fagocitose / Cartilagem Articular / Condrócitos Limite: Animals Idioma: En Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Fagocitose / Cartilagem Articular / Condrócitos Limite: Animals Idioma: En Ano de publicação: 2004 Tipo de documento: Article