Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
Bioorg Med Chem Lett
; 14(21): 5413-6, 2004 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-15454236
ABSTRACT
Structure-activity relationships (SAR) of a weakly active class of CCR2b inhibitors were utilized to initiate a lead evolution program employing the Drug Discovery Engine. Several alternative structural series have been discovered that display nanomolar activity in the CCR2b binding and CCR2b-mediated chemotaxis assays.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Quimiocinas
/
Diaminas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article