Asparaginase inhibition of adhesion of type 1-fimbriated and P-fimbriated Escherichia coli to epithelial cell receptors.
Appl Microbiol Biotechnol
; 66(1): 71-3, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15455180
ABSTRACT
The 3D structures of Fim H and PapG proteins complexed with the host carbohydrate receptor demonstrate that both utilize binding-pocket asparagines for contact or stabilization with the carbohydrate. Pretreatment of whole bacteria with asparaginase resulted in decreased fimbriae-mediated attachment to urinary epithelial cells. Enzyme treatment of bacteria pre-adhered to epithelial cells removed more uropathogenic E. coli than the indigenous flora attached to them.
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Base de dados:
MEDLINE
Assunto principal:
Asparaginase
/
Sistema Urinário
/
Aderência Bacteriana
/
Fímbrias Bacterianas
/
Escherichia coli
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article