Antisperm antibodies in seminal plasma of spinal cord-injured men.
Urology
; 39(3): 243-7, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1546417
ABSTRACT
Central to the problem of reproductive rehabilitation of spinal cord-injured men treated by assisted ejaculatory techniques is the consistent observation of deficient semen quality. Most studies have reported asthenospermia despite the presence of normal sperm concentration in most men undergoing these procedures. To date little attention has been given to the incidence and relevance of sperm autoimmunity in this group. In 9 anejaculatory spinal cord-injured men, electroejaculation was performed. Antegrade ejaculates were obtained in 7 men and analyzed. Mean sperm antegrade concentration was 74.4 +/- 113 x 10(6)/mL with a mean motile sperm concentration of 28.6 +/- 54.0 x 10(6)/mL. Enzyme-linked immunosorbent assay (ELISA)-determined antisperm antibody response was positive in the seminal plasma of 5 of 7 patients. Because of the disproportionately high incidence of an immunologic factor in men with neurogenic infertility, sperm autoimmunity should be considered among the important causes underlying their seminal dysfunction.
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Base de dados:
MEDLINE
Assunto principal:
Sêmen
/
Autoanticorpos
/
Espermatozoides
/
Traumatismos da Medula Espinal
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article