Nitric oxide and effect of a radical scavenger N-tert-butyl-alpha-phenylnitrone on stroke in a rat model.
Pharmacology
; 73(2): 76-80, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-15467301
ABSTRACT
To characterize the role of nitric oxide (NO) in stroke, NO was measured using an in vivo microdialysis technique and electron spin resonance spectrometry in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP), stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). The brain dialysate NO level was higher in SHRSP than in WKY. NO was not detected in M-SHRSP hippocampus microdialysate after stroke except after the administration of N-tert-butyl-alpha-phenylnitrone (PBN). In addition, very little NO was generated in M-SHRSP brain tissue with hemorrhage. These data demonstrate an association between NO and stroke in M-SHRSP. Further, PBN administration results in maintenance of NO levels after stroke in M-SHRSP.
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Base de dados:
MEDLINE
Assunto principal:
Sequestradores de Radicais Livres
/
Acidente Vascular Cerebral
/
Óxido Nítrico
/
Óxidos de Nitrogênio
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article