Association of obesity with inflammation in chronic kidney disease: a cross-sectional study.
J Ren Nutr
; 14(4): 201-7, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15483779
ABSTRACT
OBJECTIVE:
As adipose tissue releases inflammatory cytokines, obesity is associated with elevated C-reactive protein (CRP) levels in the general population. We examined the cross-sectional association of body mass index (BMI) with CRP in patients with chronic kidney disease (CKD).DESIGN:
Cross-sectional study. SETTING ANDPARTICIPANTS:
Ninety-four CKD patients with varying levels of renal function seen at the University of Utah outpatient renal clinic were studied.METHODS:
Data on demographics (age, gender, race), comorbidity (diabetes mellitus, hypertension, myocardial infarction/angina, cerebrovascular disease, peripheral vascular disease, and smoking) and anthropometry (height and weight) were obtained by patient interview and chart reviews. High-sensitivity CRP was measured by the N-latex assay on a BN II nephelometer. MAIN OUTCOMEMEASURE:
Risk factors of high CRP.RESULTS:
In a multivariable logistic regression model, when compared with patients with a BMI < 25, the odds of CRP > 3.0 mg/L were 2.5-fold (95% CI, 1.02 to 5.99) higher in patients with BMI > or = 30. In a stepwise multiple linear regression model, BMI (regression coefficient [beta] = 0.06; 95% CI, 0.03 to 0.1; P < .01), serum creatinine (beta = 0.16; 95% CI, 0.04 to 0.3; P = .01) and age (beta = 0.01; 95% CI, -0.001 to 0.03; P = .05) were significantly associated with log transformed CRP.CONCLUSION:
These data suggest that as in the general population, in CKD patients, obesity, a traditional risk factor for atherosclerosis, is associated with inflammation, a novel risk factor for atherosclerosis.
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Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Inflamação
/
Nefropatias
/
Obesidade
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article