Vascular frontiers without borders: multifaceted roles of platelet-derived growth factor (PDGF) in supporting postnatal angiogenesis and lymphangiogenesis.
Cancer Cell
; 6(4): 307-9, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15488752
ABSTRACT
The platelet-derived growth factor (PDGF) family of growth factors, which primarily serves the function of stabilizing vascular networks, has now been shown to play a role in promoting tumor lymphangiogenesis. PDGF-BB, independent of VEGFR-3 signaling, induces tumor growth and metastasis in part through supporting lymphangiogenesis. These data suggest that targeting the PDGF/PDGF-receptor signaling pathway will provide a novel strategy to block tumor neoangiogenesis and lymphangiogenesis, thereby inhibiting tumor growth and metastasis.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Derivado de Plaquetas
/
Linfangiogênese
/
Neoplasias
/
Neovascularização Patológica
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article