DNA methyltransferase inhibitors: old and new drugs for an epigenetic cancer therapy.
Trends Pharmacol Sci
; 25(11): 551-4, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15491775
ABSTRACT
The pharmacological inhibition of DNA methyltransferases provides novel opportunities for the therapy of human cancers. Several Phase III trials of DNA methyltransferase inhibitors have been completed successfully, but the efficacy of these compounds appears to be compromised by their lack of specificity. To address this issue, much work has been focused on defining the functional characteristics of human DNA methyltransferases. This knowledge will be essential for the design of a new generation of pharmacological inhibitors that target epigenetic processes.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
DNA (Citosina-5-)-Metiltransferases
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article