Quinolone-resistant Haemophilus influenzae: determination of mutant selection window for ciprofloxacin, garenoxacin, levofloxacin, and moxifloxacin.
Antimicrob Agents Chemother
; 48(11): 4460-2, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15504883
Stepwise selection of ciprofloxacin-resistant Haemophilus influenzae mutants produced first-, second-, third-, and fourth-step substitutions in GyrA (S84Y), ParC (S84R), GyrA (D88N), and ParC (E88K), respectively. Successive mutations raised the mutant selection window. The wild-type selection window for garenoxacin, levofloxacin, and moxifloxacin was also measured.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Haemophilus influenzae
/
Antibacterianos
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Mutação
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article