Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension.
Mol Cell Biol
; 24(22): 9736-43, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15509778
ABSTRACT
The physiological role of an orphan G protein-coupled receptor, LGR5, was investigated by targeted deletion of this seven-transmembrane protein containing a large N-terminal extracellular domain with leucine-rich repeats. LGR5 null mice exhibited 100% neonatal lethality characterized by gastrointestinal tract dilation with air and an absence of milk in the stomach. Gross and histological examination revealed fusion of the tongue to the floor of oral cavity in the mutant newborns and immunostaining of LGR5 expression in the epithelium of the tongue and in the mandible of the wild-type embryos. The observed ankyloglossia phenotype provides a model for understanding the genetic basis of this craniofacial defect in humans and an opportunity to elucidate the physiological role of the LGR5 signaling system during embryonic development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Língua
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Receptores Acoplados a Proteínas G
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article