A mass spectrometric investigation of non-covalent interactions between ruthenium complexes and DNA.
Dalton Trans
; (17): 2683-90, 2004 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-15514752
ABSTRACT
Electrospray ionisation mass spectrometry was used to investigate reactions between six ruthenium compounds and three different non self-complementary duplex oligonucleotides containing 16 base pairs. Each of the compounds studied formed non-covalent complexes containing between one and five ruthenium molecules bound to DNA. Competition experiments involving duplex 16mers and pairs of ruthenium compounds were used to determine the order of relative binding affinities of the metal compounds. Other competition experiments involving ruthenium compounds, and the organic DNA binding agents daunomycin and distamycin, provided information about the sites and modes of DNA binding of the ruthenium compounds.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Rutênio
/
DNA
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article