Association studies for finding cancer-susceptibility genetic variants.
Nat Rev Cancer
; 4(11): 850-60, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15516958
ABSTRACT
Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.
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Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Predisposição Genética para Doença
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article