The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity.
J Exp Med
; 200(9): 1145-56, 2004 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-15520246
ABSTRACT
The chemokine receptor CXCR4 is expressed in B cells at multiple stages of their development. CXCR4 function in humoral immunity has not been fully investigated. We have generated gene-targeted mice in which CXCR4 can be selectively inactivated in B cells and have shown that it is required for retention of B cell precursors in the bone marrow. CXCR4-deficient B cell precursors that migrated prematurely became localized in splenic follicles despite their unresponsiveness to CXCL13. Concomitantly, mature B cell populations were reduced in the splenic marginal zone and primary follicles, and in the peritoneal cavity in the mutant animals, as were T-independent antibody responses. In addition, aberrant B cell follicles formed ectopically in intestinal lamina propria around Peyer's patches. These findings establish an important role for CXCR4 in regulating homeostasis of B cell compartmentalization and humoral immunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Receptores CXCR4
/
Homeostase
/
Formação de Anticorpos
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article