A randomized trial of atropine regimens for treatment of moderate amblyopia in children.
Ophthalmology
; 111(11): 2076-85, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15522375
ABSTRACT
OBJECTIVE:
To compare daily atropine to weekend atropine as prescribed treatments for moderate amblyopia in children younger than 7 years.DESIGN:
Prospective, randomized multicenter clinical trial (30 sites).PARTICIPANTS:
One hundred sixty-eight children younger than 7 years with amblyopia in the range of 20/40 to 20/80 associated with strabismus, anisometropia, or both. INTERVENTION Randomization either to daily atropine or to weekend atropine for 4 months. Partial responders were continued on the randomized treatment until no further improvement was noted. MAIN OUTCOMEMEASURE:
Visual acuity (VA) in the amblyopic eye after 4 months.RESULTS:
The improvement in VA of the amblyopic eye from baseline to 4 months averaged 2.3 lines in each group. The VA of the amblyopic eye at study completion was either (1) at least 20/25 or (2) better than or equal to that of the sound eye in 39 children (47%) in the daily group and 45 children (53%) in the weekend group. The VA of the sound eye at the end of follow-up was reduced by 2 lines in one patient in each group. Stereoacuity outcomes were similar in the 2 groups.CONCLUSIONS:
Weekend atropine provides an improvement in VA of a magnitude similar to that of the improvement provided by daily atropine in treating moderate amblyopia in children 3 to 7 years old. This article contains additional online-only material available at http//www.ophsource.com/periodicals/ophtha.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Atropina
/
Ambliopia
/
Midriáticos
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article