Potential of DNA microarrays for developing parallel detection tools (PDTs) for microorganisms relevant to biodefense and related research needs.
Biosens Bioelectron
; 20(4): 668-83, 2004 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-15522582
ABSTRACT
Development of parallel detection tools using microarrays is critically reviewed in view of the need for screening multiple microorganisms in a single test. Potential research needs with respect to probe design and specificity, validation, sample concentration, selective target enrichment and amplification, and data analysis are discussed. Data illustrating selected probe design issues for detecting multiple targets in mixed microbial systems is presented. Challenges with respect to cost, time, and ease of use compared to other methods are also summarized.
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Base de dados:
MEDLINE
Assunto principal:
Pesquisa
/
Avaliação da Tecnologia Biomédica
/
Bactérias
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Bioterrorismo
/
Eucariotos
/
Fungos
Tipo de estudo:
Diagnostic_studies
/
Health_technology_assessment
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article