Regulation of follicle-stimulating and luteinizing hormone receptor signaling by.
Endocrine
; 25(1): 49-54, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15545706
ABSTRACT
Follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) belong to the super-family of G protein-coupled receptors (GPCR); GPCRs are negatively regulated by RGS ("regulators of G protein signaling") proteins. In this study we evaluated the effects of RGS3 and RGS10 on FSHR and LHR ligand binding and effector coupling. FSHR and LHR ligand binding were unchanged in the presence of RGS3 or RGS10. However, signaling by FSHR and LHR was diminished by RGS3 but not by RGS10. This constitutes the first demonstration of an interaction between RGS proteins and LH and FSH signaling pathways and identifies a mechanism for negative regulation of RGS3 on FSHR and LHR signaling.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Receptores do FSH
/
Receptores do LH
/
Transdução de Sinais
/
Proteínas RGS
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article