TGF-beta activation by traction?
Trends Cell Biol
; 14(12): 657-9, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15564041
ABSTRACT
Transforming growth factor (TGF)-betas are powerful cytokines that are secreted as inactive (latent) precursors into the extracellular space. To exert their pleiotropic functions, latent TGF-betas require activation. This requisite restricts TGF-beta signaling to tissues that express TGF-beta-activating proteins such as the adhesion molecule alphavbeta6 integrin. Recent work has uncovered the molecular mechanism by which alphavbeta6 integrin activates latent TGF-beta. Latent-TGF-beta-binding protein 1 has been identified as being the major component of this process, and the integrin-interacting region has been mapped to a poorly conserved sequence stretch called the hinge region.
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Base de dados:
MEDLINE
Assunto principal:
Integrinas
/
Fator de Crescimento Transformador beta
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Antígenos de Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article