Bifidobacterium longum as an oral delivery system of endostatin for gene therapy on solid liver cancer.
Cancer Gene Ther
; 12(2): 133-40, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-15565182
To overcome difficulties that hampered widespread application of a specific delivery system in cancer gene therapy and to inhibit the growth of solid liver cancer, we utilized a strain of Bifidobacterium longum as a delivery system to transport an endostatin gene that can inhibit growth of tumor. The B. longum strain with the endostatin gene (B. longum-En) was taken orally by tumor-bearing nude mice through drencher preparation. The results showed that B. longum-En could strongly inhibit the growth of solid liver tumor in nude mice and prolong the survival time of tumor-bearing nude mice. Furthermore, tumor growth was inhibited more efficiently when the B. longum-En treatment included selenium. Enriching the B. longum-En treatment with selenium improves the activity of NK and T cells and stimulates the activity of IL-2 and TNF-alpha in BALB/c mice. These results suggest that B. longum may be a highly specific and efficient vector for transporting anticancer genes in cancer gene therapy.
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Base de dados:
MEDLINE
Assunto principal:
Bifidobacterium
/
Terapia Genética
/
Sistemas de Liberação de Medicamentos
/
Endostatinas
/
Neoplasias Hepáticas Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article