A new ene-triyne antibiotic from the fungus Baeospora myosura.
J Nat Prod
; 67(11): 1900-2, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15568786
ABSTRACT
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.
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Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Acetileno
/
Basidiomycota
/
Antibacterianos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article