p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells.
Brain Res
; 1030(2): 297-302, 2004 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-15571679
ABSTRACT
Kainic acid (KA) treatment induced neuronal death and apoptosis in murine cerebellar granule cells (CGNs) cultures from both wild-type and knockout p21(-/-) mice. There was not statistically significant difference in the percentage of neuronal apoptosis among strains. KA-induced neurotoxicity was prevented in the presence of NBQX (20 microM) and GYKI 52446 (20 microM), but not by z-VAD-fmk, suggesting that caspases are not involved in the apoptotic process. Data suggest that p21(WAF/Cip) was unable to modulate KA-induced apoptosis in murine CGNs.
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Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Cerebelo
/
Apoptose
/
Proteínas de Ciclo Celular
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article