Synthesis and in vitro study of novel Mannich bases as antibacterial agents.

Joshi, Sheela; Khosla, Navita; Khare, Deepak; Sharda, Rakesh

Joshi, Sheela; Khosla, Navita; Khare, Deepak; Sharda, Rakesh.

Afiliação

Joshi S; School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshila Campus, Khandwa Road, Indore, Madhya Pradesh (M.P.), India. spjoshi11@rediffmail.com

Bioorg Med Chem Lett ; 15(1): 221-6, 2005 Jan 03.

Article em En | MEDLINE | ID: mdl-15582443

ABSTRACT

ABSTRACT

A series of novel Mannich bases derived from 5-chloro-2-methoxybenzamide and sulfonamides/amines have been synthesised and the antibacterial activities were evaluated against various Gram positive and Gram negative strains of bacteria. Some of the synthesized compounds showed superior in vitro activities as compared to their parent sulfonamides.

Assuntos

Antibacterianos/síntese química; Antibacterianos/química; Antibacterianos/farmacologia; Técnicas In Vitro; Testes de Sensibilidade Microbiana; Análise Espectral/métodos

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