Identification of mutations in proviral long terminal repeats of HIV type 1-infected subjects naive to drug therapy.
AIDS Res Hum Retroviruses
; 20(9): 1019-21, 2004 Sep.
Article
em En
| MEDLINE
| ID: mdl-15585090
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5' long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp deletion preceding the NF kappa B elements and a duplication of the RBF-2 motif. A higher overall frequency of mutations within the LTR occurred within NFAT-1 and Sp-1 sequences. Importantly, a novel 16-bp deletion was found in the distal NFAT-1 site.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Repetição Terminal Longa de HIV
/
HIV-1
/
Provírus
/
Mutação
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article