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Weekly gemcitabine, paclitaxel, oxaliplatin combination chemotherapy in patients with Cisplatin-refractory germ cell tumor: preliminary experience.
De Giorgi, Ugo; Rosti, Giovanni; Papiani, Giorgio; Aieta, Michele; Fochessati, Francesca; Paoluzzi, Luca; Valduga, Francesco; Marangolo, Maurizio.
Afiliação
  • De Giorgi U; Department of Oncology, Ospedale Santa Maria delle Croci, Ravenna, Italy. ugo.degiorgi@yahoo.com
Am J Clin Oncol ; 27(5): 457-60, 2004 Oct.
Article em En | MEDLINE | ID: mdl-15596910
ABSTRACT
Although the overall cure rate for advanced germ cell tumor (GCT) is high, the prognosis for patients with cisplatin-refractory GCT remains poor. Gemcitabine, paclitaxel, and oxaliplatin have shown significant activity as single agents in these patients. We investigated the activity and tolerance of a weekly gemcitabine, paclitaxel, oxaliplatin chemotherapy regimen. From September 2000 to February 2002, 9 patients with cisplatin-refractory GCT were treated with gemcitabine 800 mg/m2, paclitaxel 70 mg/m2, and oxaliplatin 50 mg/m2, days 1, 8, and 15, every 4 weeks. Only 1 patient stayed on schedule. In 7 patients, chemotherapy treatment was modified due to grade 3-4 hematological toxicity, whereas in another patient, who received high-dose chemotherapy 2 months before, chemotherapy was administered biweekly. In total, 21 cycles were administered with a median of 2 cycles for each patient. One patient achieved a partial remission lasting 5 months, 1 had disease stabilization for 5 months, whereas 7 had progressive disease. This chemotherapy regimen was not feasible in our patient population. Recently, oxaliplatin at full doses, but not as weekly administration, has appeared to possess activity in cisplatin-refractory GCT. Thus, we plan a phase II study protocol of the oxaliplatin and gemcitabine combination at full doses every 3 weeks.
Assuntos
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Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias Testiculares / Protocolos de Quimioterapia Combinada Antineoplásica / Germinoma / Desoxicitidina / Neoplasias do Mediastino Tipo de estudo: Guideline Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias Testiculares / Protocolos de Quimioterapia Combinada Antineoplásica / Germinoma / Desoxicitidina / Neoplasias do Mediastino Tipo de estudo: Guideline Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2004 Tipo de documento: Article