CD8+ T-cell response against MUC1-derived peptides in gastrointestinal cancer survivors.
Cancer Immunol Immunother
; 54(8): 750-8, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-15614528
ABSTRACT
The tumor-associated antigens CEA, MUC1 and Her2/neu are broadly expressed in gastrointestinal tumors, and are attractive candidates for targeting by T-cell-based immunotherapy. However, little is known about the natural cytotoxic T-cell response of patients suffering from colorectal or gastric carcinoma against these three as well as other antigens. Using a quantitative reverse transcription-polymerase chain reaction-based assay for IFN-gamma, we analyzed the CD8+ T-cell repertoire present in the blood of HLA-A2+ gastrointestinal tumor survivors against five known epitopes derived from CEA, MUC1 and Her2/neu. The results show that most of the patients (16 from 22 tested) have detectable, peripheral CD8+ T cells directed against at least one of these three proteins. Interestingly, the majority of these patients reacts to the two MUC1-derived HLA-A*0201 epitopes tested (14 from 16), demonstrating that this protein represents one dominant target for CD8+ T cells in gastrointestinal cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Neoplasias Colorretais
/
Sobreviventes
/
Linfócitos T CD8-Positivos
/
Mucina-1
Limite:
Aged
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article