Quantitative determination of urinary 8-hydroxy-2'-deoxyguanosine level in healthy Japanese volunteers.
Biofactors
; 22(1-4): 249-53, 2004.
Article
em En
| MEDLINE
| ID: mdl-15630292
ABSTRACT
8-hydroxy-2'-deoxyguanosine (8-OHdG), as a measure of oxidative stress, was measured in healthy Japanese volunteers using an ELISA (New 8-OHdG Check, JICA). Analysis of daytime spot urine of 83 healthy male subjects and smoking habit, exercise and age revealed significant correlation only between the urinary level of 8-OHdG and age. As the inter-individual variation of 8-OHdG of the daytime spot urine was relatively high, we next determined inter-and intra-individual variation of 5 healthy volunteers. The levels of 8-OHdG/creatinine in morning spot urine significantly correlated with 8-OHdG levels in 24-h pool urine. Thus, a morning spot urine sample can be used for the measurement of 8-OHdG instead of inconvenient 24-h sampling.
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Base de dados:
MEDLINE
Assunto principal:
Desoxiguanosina
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article