Effects of environmental and natural estrogens on vitellogenin production in hepatocytes of the brown frog (Rana temporaria).
Aquat Toxicol
; 71(1): 97-101, 2005 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-15642635
ABSTRACT
The objective of this study was to investigate the ability of the natural estrogens and synthetic estrogens as well as the estrogen mimics to induce estrogen-receptor mediated vitellogenesis in primary hepatocytes of the brown frog (Rana temporaria). Based on EC50 values the following order was determined for the potency of the estrogens 17beta-estradiol (EC50 19-43 nM) approximately ethynylestradiol (EC50 13-80 nM)>estrone (EC50 218-241 nM)>DES (EC50 338-3537 nM). Exposure to bisphenol A and methoxychlor concentrations up to 100 microM did not have any effect on in vitro vitellogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Rana temporaria
/
Vitelogênese
/
Estrogênios
/
Etinilestradiol
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article