5-hydroxyuracil can form stable base pairs with all four bases in a DNA duplex.
Chem Commun (Camb)
; (3): 400-2, 2005 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-15645051
ABSTRACT
NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.
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Base de dados:
MEDLINE
Assunto principal:
Uracila
/
DNA
/
Pareamento de Bases
/
Nucleosídeos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article