A modular, one-pot, four-component synthesis of polysubstituted 1,3-oxazolidines.
J Org Chem
; 70(3): 1042-5, 2005 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-15675866
A modular, one-pot, two-step, four-component synthesis of polysubstituted 1,3-oxzolidines is described. The method comprises two linked domino processes: an organocatalyzed domino reaction of alkyl propiolate and an aliphatic aldehydes and a microwave-assisted amine addition cyclization domino process. An alternative modular, one-pot, three-step, four-component synthesis has also been developed by linking the organocatalyzed domino process to a sequential amine addition/Yb(OTf)(3)-catalyzed enamine cyclization reaction.
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Base de dados:
MEDLINE
Assunto principal:
Oxazóis
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article