[Leishmaniasis--oral treatment with hexadecylphosphocholine]. / Leishmaniasis: Orale Therapie mit Hexadecylphosphocholin.
Wien Klin Wochenschr
; 116 Suppl 4: 24-9, 2004.
Article
em De
| MEDLINE
| ID: mdl-15683039
ABSTRACT
Hexadecylphosphocholine (HDPC, Miltefosine, Impavido) was synthesized at the Max-Planck-Institut für Biophysikalische Chemie in Göttingen, Germany and successfully used for the therapy of cancer metastases. At the Institute of General and Tropical Hygiene of Göttingen University the antiparasitic efficacy--earlier mentioned by Croft et al. (1987)--could be established for the first time in animals after oral administration. In India Impavido has been recently registered for the treatment of visceral leishmaniasis as the first oral medication in this indication. Clinical studies in India--actually a phase IV study is running--and Columbia (cutaneous leishmaniosis) demonstrated the excellent efficacy of this oral treatment also in patients with Antimon resistance. The cure rates are above 90% with low side effects (Impavido twice 50 mg capsules daily over 28 days).
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Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Leishmaniose
/
Antiprotozoários
Tipo de estudo:
Systematic_reviews
Limite:
Adult
/
Child
/
Humans
Idioma:
De
Ano de publicação:
2004
Tipo de documento:
Article