Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.
Nat Rev Immunol
; 5(2): 171-8, 2005 02.
Article
em En
| MEDLINE
| ID: mdl-15688043
ABSTRACT
Somatic hypermutation of immunoglobulin genes occurs at both C.G pairs and A.T pairs. Mutations at C.G pairs are created by activation-induced deaminase (AID)-catalysed deamination of C residues to U residues. Mutations at A.T pairs are probably produced during patch repair of the AID-generated U.G lesion, but they occur through an unknown mechanism. Here, we compare the popular suggestion of nucleotide mispairing through polymerase error with an alternative possibility, mutation through incorporation of dUTP (or another non-canonical nucleotide).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pareamento Incorreto de Bases
/
Hipermutação Somática de Imunoglobulina
/
Nucleotídeos de Desoxiuracil
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DNA Polimerase Dirigida por DNA
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article