Molecular mechanisms of endochondral bone development.
Biochem Biophys Res Commun
; 328(3): 658-65, 2005 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-15694399
ABSTRACT
Endochondral bone development is a complex process in which undifferentiated mesenchymal cells differentiate into chondrocytes, which then undergo well-ordered and controlled phases of proliferation, hypertrophic differentiation, death, blood vessel invasion, and finally replacement of cartilage with bone. The process recapitulates basic and fundamental mechanisms of cell biology with a highly specific spatial and temporal pattern, and it thus constitutes an excellent model for the analysis of such mechanisms. In recent years, the tools provided by modern genetic both in mice and men have been instrumental in the process of identifying and dissecting basic molecular mechanisms of endochondral bone formation. This review is a brief summary of the current knowledge about some of the crucial factors involved in growth plate development.
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Base de dados:
MEDLINE
Assunto principal:
Osteócitos
/
Fatores de Transcrição
/
Osso e Ossos
/
Desenvolvimento Ósseo
/
Regulação da Expressão Gênica no Desenvolvimento
/
Condrócitos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article