Genistein protects dopaminergic neurons by inhibiting microglial activation.
Neuroreport
; 16(3): 267-70, 2005 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-15706233
ABSTRACT
Inflammation participates in the pathogenesis and progression of Parkinson's disease, in which microglia play a key role. Inhibition of microglia activation has been shown to attenuate inflammation-mediated dopaminergic neurodegeneration. In this study, we found that genistein, the primary soybean isoflavone, concentration-dependently attenuated the lipopolysaccharide-induced decrease in dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in rat mesencephalic neuron-glia cultures. Genistein also inhibited lipopolysaccharide-induced microglia activation and production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. Our results indicate that genistein may protect dopaminergic neurons from lipopolysaccharide-induced injury and its effective inhibition of microglia activation may be one of the mechanisms.
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Base de dados:
MEDLINE
Assunto principal:
Mesencéfalo
/
Dopamina
/
Microglia
/
Genisteína
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article