Structure-activity relationships of dimeric PPAR agonists.
Bioorg Med Chem Lett
; 15(5): 1497-500, 2005 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-15713415
ABSTRACT
A series of dimeric PPAR agonists were designed and tested for PPAR activity in vitro. The SAR showed that dimeric ligands with a common group or full dimeric ligands had retained or even increased PPARgamma potency. The dimeric agonist concept can be used to fine tune the subtype selectivity of PPAR agonists. The PPARgamma potency could, at least partly, be explained using molecular modeling.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Receptores Ativados por Proliferador de Peroxissomo
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article