Changes in motor cortex excitability during muscle fatigue in amyotrophic lateral sclerosis.
J Neurol Neurosurg Psychiatry
; 76(3): 429-31, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15716542
ABSTRACT
To further investigate the pathophysiology of amyotrophic lateral sclerosis (ALS), the silent period (SP) evoked by transcranial magnetic stimulation during a fatiguing muscle contraction was evaluated in 15 patients and in 15 healthy subjects. Physiological lengthening of the SP duration was not observed in patients with disease duration of > or = 2 years. Decreased intracortical inhibition, probably secondary to dysfunction of the inhibitory interneurons that modulate the corticomotoneuronal firing, appears in later stages of disease. Normal motor cortex adaptation is impaired and cortical hyperexcitability might be unmasked during fatigue in ALS patients with longer disease duration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fadiga Muscular
/
Esclerose Lateral Amiotrófica
/
Córtex Motor
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article