Genotoxic and cytotoxic effects in the bone marrow of rats exposed to a low dose of paraquat via the dermal route.
Mutat Res
; 581(1-2): 187-90, 2005 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-15725618
ABSTRACT
The genotoxic effect of the herbicide paraquat was studied in rat bone-marrow by means of the micronucleus assay. Paraquat at dose levels of 6, 15 and 30 mg/kg body weight was given to rats in a single application via the dermal route. Marrow was collected at 24, 48 and 72 h after the application. The micronucleus assay was done as recommended by standard procedures. Paraquat gave rise to an increase in the number of micronuclei in a dose-dependent manner. The number of micronucleated polychromatic erythrocytes showed a maximum at 48 h and the toxicity was further prolonged, as there was no complete recovery at 72 h. These findings suggest a genotoxic effect of paraquat even after exposure via dermal application.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Paraquat
/
Medula Óssea
/
Citotoxinas
/
Herbicidas
/
Mutagênicos
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article