Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2.
Genomics
; 12(4): 822-5, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1572656
ABSTRACT
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. Using primers derived from the known rat cDNA sequence for COMT, we have used the polymerase chain reaction to produce an amplified DNA fragment corresponding to the complete coding region of the rat gene. With this fragment as a probe, we have hybridized DNAs from two panels consisting of human/rodent and human/hamster somatic cell hybrids carrying various translocations and deletions to refine the chromosomal location of human COMT. Southern blot analysis indicates that the human COMT gene is localized to 22q11.1----q11.2, a region to which several anonymous DNA sequences, but until now, no structural genes, have been assigned.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 22
/
Catecol O-Metiltransferase
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article