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[Detection of HBcAg-specific cytotoxic lymphocytes and their association with clinical status in patients with hepatitis B].
Fan, Zhen-ping; Wang, Fu-sheng; Xu, Dong-Ping; Chu, Fu-liang; Shi, Ming; Zhou, Yu; Zhang, Ling-xia.
Afiliação
  • Fan ZP; Research Center of Biological Therapy, PLA 302nd Hospital, Beijing 100039, China.
Zhonghua Yi Xue Za Zhi ; 84(24): 2073-6, 2004 Dec 17.
Article em Zh | MEDLINE | ID: mdl-15730619
OBJECTIVE: To investigate the difference of host immune response specific to hepatitis B virus (HBV) infections between acute self-limited and chronic persistent hepatitis by quantitative analysis of HLA-A * 2402-restricted HBcAg-specific cytotoxic T lymphocyte cells (CTL) cells. METHODS: The frequency of HBV-specific CTL cells in the peripheral blood mononuclear cells (PBMCs) from 20 patients infected with HBV were quantified by ELISPOT assays and flow cytometry using one HLA-A * 2402-HBV, 7 with acute HB and 13 with chronic HB, peptide tetrameric complex. RESULTS: High frequencies of circulating HBcAg-specific CTL cells were detected in most individuals with acute HBV infection while the number of these cells was significantly reduced at the convalescent stage. HBcAg-specific CTL cells were not detected in the PBMC from individuals with chronic HBV infection except for one patient with an acute infection exacerbation. CONCLUSION: HBcAg-specific CTL cells may play a crucial role in complete clearance of HBV from patients with acute HBV hepatitis.
Assuntos
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Base de dados: MEDLINE Assunto principal: Linfócitos T Citotóxicos / Hepatite B / Antígenos do Núcleo do Vírus da Hepatite B Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: Zh Ano de publicação: 2004 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Linfócitos T Citotóxicos / Hepatite B / Antígenos do Núcleo do Vírus da Hepatite B Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: Zh Ano de publicação: 2004 Tipo de documento: Article