PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.
Oncogene
; 24(21): 3484-91, 2005 May 12.
Article
em En
| MEDLINE
| ID: mdl-15735745
ABSTRACT
Mutant p53-carrying tumors are often more resistant to chemotherapeutical drugs. We demonstrate here that the mutant p53-reactivating compound PRIMA-1(MET) acts synergistically with several chemotherapeutic drugs to inhibit tumor cell growth. Combined treatment with cisplatin and PRIMA-1(MET) resulted in a synergistic induction of tumor cell apoptosis and inhibition of human tumor xenograft growth in vivo in SCID mice. The induction of mutant p53 levels by chemotherapeutic drugs is likely to increase the sensitivity of tumor cells to PRIMA-1(MET). Thus, the combination of PRIMA-1(MET) with currently used chemotherapeutic drugs may represent a novel and more efficient therapeutic strategy for treatment of mutant p53-carrying tumors.
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Base de dados:
MEDLINE
Assunto principal:
Quinuclidinas
/
Compostos Aza
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Neoplasias Ósseas
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Adenocarcinoma
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Osteossarcoma
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Genes p53
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Cisplatino
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Apoptose
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Carcinoma Pulmonar de Células não Pequenas
/
Compostos Bicíclicos Heterocíclicos com Pontes
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article