Study of the evolution and degradation products of ciprofloxacin and oxolinic acid in river water samples by HPLC-UV/MS/MS-MS.
J Environ Monit
; 7(3): 189-95, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15735777
ABSTRACT
The results of a degradation study of the (fluoro)quinolone antibiotics ciprofloxacin and oxolinic acid in river water samples are presented in this paper. The decomposition of these compounds at ambient temperature was monitored during five months by HPLC-UV, and two consecutive degradation processes (photo- and bio/chemical-degradation) were observed in both cases although with different degradation rates. Ciprofloxacin was completely degraded after 3 months whereas 80% of oxolinic acid remained unaltered after five months of storage. The analysis of the degradation compounds formed was carried out using MS and tandem MS-MS, allowing the identification of four new ciprofloxacin transformation products not previously described in the literature. Possible degradation pathways for this antibiotic in river water are proposed.
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Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Ciprofloxacina
/
Ácido Oxolínico
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article