The lambda5-VpreB1 locus--a model system for studying gene regulation during early B cell development.
Semin Immunol
; 17(2): 121-7, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15737573
ABSTRACT
The lambda5 and VpreB genes encode the components of the surrogate light-chain, which forms part of the pre-B cell receptor. In mouse, the lambda5 and VpreB1 genes of mouse are closely linked and coordinately regulated by a locus control region (LCR). Activation of the genes in pro-B cells depends on the combined effects of early B cell factor (EBF) and the E2A factors E12 and E47. Silencing of lambda5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Glicoproteínas de Membrana
/
Linfócitos B
/
Regulação da Expressão Gênica no Desenvolvimento
/
Inativação Gênica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article